U.S. Route 385 is a spur of U.S. Route 85 that runs for 1,206 miles (1,941 km) from Deadwood, South Dakota to Big Bend National Park in Texas
U.S. 385 enters South Dakota south of Oelrichs. It is overlapped with U.S. Route 18 between Oelrichs and Hot Springs. It turns north and enters Wind Cave National Park before turning west to go through Pringle. At Custer, it begins an overlap with U.S. Route 16, which ends near Hill City. It gradually turns northwesterly and ends at an intersection with U.S. Route 85 at Deadwood.
Motels in communities along the way: